Genetic testing has become an integral component of the diagnostic evaluation of patients with suspected primary immunodeficiency diseases. Results of genetic testing can have profound impact on clinical management decisions. Clinical providers must therefore demonstrate proficiency in interpreting genetic data.
Because of the need for increased knowledge regarding this practice, the American Academy of Allergy, Asthma, and Immunology Primary Immunodeficiency Diseases Committee established a Work Group that reviewed and summarized information concerning appropriate methods, tools, and resources for evaluating variants identified by genetic testing. Strengths and limitations of tests frequently ordered by clinicians were examined.
Summary statements and tables were then developed to guide the interpretation process. Finally, the need for research and collaboration was emphasized. Greater understanding of these important concepts will improve the diagnosis and management of patients with suspected primary immunodeficiency diseases.
Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology.
Providers caring for patients with mastocytosis are tasked with the decision to consider therapeutic options. This can come with some trepidation because information available in the public domain lists numerous mast cell (MC) activators based on data that do not discriminate between primates, rodents, and MC lines; do not consider dosage; and do not take into account previous exposure and resultant clinical findings.
anti-FBXW9 |
YF-PA21352 |
Abfrontier |
50 ul |
EUR 435.6 |
Description: Mouse polyclonal to FBXW9 |
anti-FBXW9 |
YF-PA21353 |
Abfrontier |
50 ug |
EUR 435.6 |
Description: Mouse polyclonal to FBXW9 |
FBXW9 Blocking Peptide |
33R-7018 |
Fitzgerald |
100 ug |
EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FBXW9 antibody, catalog no. 70R-10074 |
Human FBXW9 shRNA Plasmid |
20-abx963386 |
Abbexa |
|
|
|
FBXW9 Recombinant Protein (Rat) |
RP201086 |
ABM |
100 ug |
Ask for price |
FBXW9 Recombinant Protein (Human) |
RP058557 |
ABM |
100 ug |
Ask for price |
FBXW9 Recombinant Protein (Mouse) |
RP134171 |
ABM |
100 ug |
Ask for price |
Polyclonal FBXW9 Antibody (N-term) |
APR04215G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human FBXW9 (N-term). This antibody is tested and proven to work in the following applications: |
Fbxw9 ORF Vector (Rat) (pORF) |
ORF067030 |
ABM |
1.0 ug DNA |
EUR 607.2 |
FBXW9 ORF Vector (Human) (pORF) |
ORF019520 |
ABM |
1.0 ug DNA |
Ask for price |
Fbxw9 ORF Vector (Mouse) (pORF) |
ORF044725 |
ABM |
1.0 ug DNA |
EUR 607.2 |
FBXW9 sgRNA CRISPR Lentivector set (Human) |
K0767801 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Fbxw9 sgRNA CRISPR Lentivector set (Rat) |
K6502701 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Fbxw9 sgRNA CRISPR Lentivector set (Mouse) |
K4917701 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
FBXW9 sgRNA CRISPR Lentivector (Human) (Target 1) |
K0767802 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXW9 sgRNA CRISPR Lentivector (Human) (Target 2) |
K0767803 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXW9 sgRNA CRISPR Lentivector (Human) (Target 3) |
K0767804 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Rat) (Target 1) |
K6502702 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Rat) (Target 2) |
K6502703 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Rat) (Target 3) |
K6502704 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K4917702 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K4917703 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxw9 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K4917704 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXW9 Protein Vector (Human) (pPB-C-His) |
PV078077 |
ABM |
500 ng |
Ask for price |
FBXW9 Protein Vector (Human) (pPB-N-His) |
PV078078 |
ABM |
500 ng |
Ask for price |
FBXW9 Protein Vector (Human) (pPM-C-HA) |
PV078079 |
ABM |
500 ng |
Ask for price |
FBXW9 Protein Vector (Human) (pPM-C-His) |
PV078080 |
ABM |
500 ng |
Ask for price |
FBXW9 Protein Vector (Rat) (pPB-C-His) |
PV268118 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Rat) (pPB-N-His) |
PV268119 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Rat) (pPM-C-HA) |
PV268120 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Rat) (pPM-C-His) |
PV268121 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Mouse) (pPB-C-His) |
PV178898 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Mouse) (pPB-N-His) |
PV178899 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Mouse) (pPM-C-HA) |
PV178900 |
ABM |
500 ng |
EUR 723.6 |
FBXW9 Protein Vector (Mouse) (pPM-C-His) |
PV178901 |
ABM |
500 ng |
EUR 723.6 |
Fbxw9 3'UTR Luciferase Stable Cell Line |
TU204534 |
ABM |
1.0 ml |
Ask for price |
Fbxw9 3'UTR GFP Stable Cell Line |
TU254534 |
ABM |
1.0 ml |
Ask for price |
Fbxw9 3'UTR GFP Stable Cell Line |
TU156468 |
ABM |
1.0 ml |
Ask for price |
Fbxw9 3'UTR Luciferase Stable Cell Line |
TU106468 |
ABM |
1.0 ml |
Ask for price |
FBXW9 3'UTR GFP Stable Cell Line |
TU057815 |
ABM |
1.0 ml |
EUR 1672.8 |
FBXW9 3'UTR Luciferase Stable Cell Line |
TU007815 |
ABM |
1.0 ml |
EUR 1672.8 |
F-Box/WD Repeat-Containing Protein 9 (FBXW9) Antibody |
abx029562-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
F-Box/WD Repeat-Containing Protein 9 (FBXW9) Antibody |
abx029562-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
FBXW9 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
K0767805 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
K6502705 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
K4917705 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Human F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E01F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Human F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E01F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Human F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E01F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Human F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E06F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E06F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E06F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E02F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E02F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E02F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E04F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E04F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E04F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E08F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E08F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E08F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E03F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E03F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E03F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E07F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E07F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E07F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Bovine F- box/WD repeat- containing protein 9, FBXW9 ELISA KIT |
ELI-48586b |
Lifescience Market |
96 Tests |
EUR 1113.6 |
Human F- box/WD repeat- containing protein 9, FBXW9 ELISA KIT |
ELI-48587h |
Lifescience Market |
96 Tests |
EUR 988.8 |
FBXW9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
K0767806 |
ABM |
1.0 ug DNA |
EUR 200.4 |
FBXW9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
K0767807 |
ABM |
1.0 ug DNA |
EUR 200.4 |
FBXW9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
K0767808 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
K6502706 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
K6502707 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
K6502708 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
K4917706 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
K4917707 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxw9 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
K4917708 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Monkey F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E09F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E09F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E09F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E05F0340-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E05F0340-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig F box/WD repeat containing protein 9(FBXW9) ELISA kit |
E05F0340-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box/WD repeat containing protein 9(FBXW9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
This being said, there is support in the literature for an enhanced MC response in some patients with mastocytosis and in cases in which there is a greater incidence of adverse reactions associated with certain antigens, such as venoms and drugs. Thus this report provides a comprehensive guide for those providers who must decide on therapeutic options in the management of patients with clonal MC disease.